Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16875 | isoform PFKFB3, bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, EC 2.7.1.105 and EC 3.1.3.46, respectively | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U2-OS cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of microRNA miR-26b represses PFKFB3 mRNA and protein levels followed by modulation of the expression of glycolytic components such as LDHA, GLUT-1 and markers of invasion and cell cycle such as MMP-9, MMP-2, cyclin D1 and p27. The binding site for miR-26b is predicted in the 3'-untranslated region of the PFKFB3 gene | Homo sapiens |