Literature summary for 3.1.3.46 extracted from

Tang, Y.; Kwon, H.; Neel, B.A.; Kasher-Meron, M.; Pessin, J.B.; Yamada, E.; Pessin, J.E.
The fructose-2,6-bisphosphatase TIGAR suppresses NF-kappaB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC (2018), J. Biol. Chem., 293, 7578-7591 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BZA9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
3T3-L1 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
TIGAR	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	TIGAR potently inhibits NF-kappaB-dependent gene expression by suppressing the upstream activation of IKKbeta phosphorylation and kinase activation. Inhibition occurs through a direct binding competition between NEMO and TIGAR for association with the linear ubiquitination assembly complex LUBAC. A TIGAR phosphatase activity-deficient mutant is equally effective as wild-type TIGAR in inhibiting NEMO linear ubiquitination. TIGAR knockout mice display enhanced adipose tissue NF-kappaB signaling, and adipocyte-specific overexpression of TIGAR suppresses adipose tissue NF-kappaB signaling	Mus musculus

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Release 2023.1 (January 2023)