Literature summary for 3.1.3.46 extracted from

Langer, S.; Kaminski, M.T.; Lenzen, S.; Baltrusch, S.
Endogenous activation of glucokinase by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is glucose dependent (2010), Mol. Endocrinol., 24, 1988-1997.

Search for more literature for 3.1.3.46

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of PFK-2/FBPase-2 in MIN6 cells	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of PFK-2/FBPase-2 in MIN6 cells results in increased insulin secretion	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	-	Rattus norvegicus
PFK-2/FBPase-2	-	Rattus norvegicus

General Information

General Information	Comment	Organism
metabolism	analysis of glucokinase/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase complex formation, binding and activation of GK by PFK-2/FBPase-2 in beta-cells is promoted by glucose, resulting in an enhancement of insulin secretion at stimulatory glucose concentrations, without affecting basal insulin secretion	Rattus norvegicus
physiological function	the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase acts as an endogenous glucokinase activator	Rattus norvegicus

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Release 2023.1 (January 2023)