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Literature summary for 3.1.3.46 extracted from

  • Hines, J.K.; Chen, X.; Nix, J.C.; Fromm, H.J.; Honzatko, R.B.
    Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition (2007), J. Biol. Chem., 282, 36121-36131.
    View publication on PubMed
Search for more literature for 3.1.3.46

Cloned(Commentary)

Cloned (Comment) Organism
as selenomethionine-substituted protein Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
as hanging drops in vapor diffusion VDX plates in complex with Mg2+ or Zn2+ and beta-D-fructose 2,6-bisphosphate Sus scrofa
as hanging drops in vapor diffusion VDX plates with Mg2+, citrate and beta-D-fructose 2,6-bisphosphate Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
AMP beta-D-fructose 2,6-bisphosphate has no effect on AMP inhibition Escherichia coli
AMP beta-D-fructose 2,6-bisphosphate enhances AMP inhibition Sus scrofa

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by Cibacron Blue-Sepharose and Sephadex G-50 column chromatography Escherichia coli
by Cibacron Blue-Sepharose and Sephadex G-50 column chromatography Sus scrofa

Reaction

Reaction Comment Organism Reaction ID
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate beta-D-fructose 2,6-bisphosphate induces a global conformational change in the absence of AMP Sus scrofa
a
beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate the complex of E. coli FBPase with beta-D-fructose 2,6-bisphosphate remains in the R-state with dynamic loops in the engaged conformation Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-D-fructose 2,6-bisphosphate + H2O
-
 Escherichia coli D-fructose 6-phosphate + phosphate
-
 ?
beta-D-fructose 2,6-bisphosphate + H2O
-
 Sus scrofa D-fructose 6-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Escherichia coli
6-phosphofructo-2-kinase/fructose-2 6-biphosphatase
-
 Sus scrofa
FBPase
-
 Escherichia coli
FBPase
-
 Sus scrofa