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Literature summary for 3.1.3.46 extracted from
- 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis (2006), Curr. Opin. Clin. Nutr. Metab. Care, 9, 535-539.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | PFKFB3 is constitutively expressed in human leukemias and solid tumor cells, inhibitors could act as antineoplastic agents | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| KDO-phosphatase knockout, enzyme is encoded by 4 genes, PFKFB1-4, PFKFB3 is activated by mitogenic, inflammatory and hypoxic stimuli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate + H2O | - |
Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase | - |
Homo sapiens |
| PFK-2/FBPase | - |
Homo sapiens |
| PFKFB1 | - |
Homo sapiens |
| PFKFB2 | - |
Homo sapiens |
| PFKFB3 | - |
Homo sapiens |
| PFKFB4 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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