Cloned (Comment) | Organism |
---|---|
gene PFKFB4, DNA and amino acid sequence determination, expression analysis in DB-1 melanoma cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dimethyloxalylglycine | inhibits the splice isozyme PFKFB-4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-fructose 2,6-bisphosphate + H2O | Homo sapiens | the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition | D-fructose 6-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16877 | PFKFB4 gene, promoter region, and 5' untranslated region, partial sequence; minor splice isozyme PFKFB-4, major isozyme PFKFB-3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DB-1 cell | melanoma cell line, minor splice isozyme PFKFB-4, major isozyme is PFKFB-3, isozyme PFKFB-4 is overexpressed in hypoxic conditions | Homo sapiens | - |
melanoma cell | minor splice isozyme PFKFB-4, major isozyme is PFKFB-3 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-fructose 2,6-bisphosphate + H2O | the enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level, which is a major allosteric activator of 6-phosphofructo 1-kinase, a key regulatory enzyme in glycolysis, the minor splice isozyme PFKFB-4 is responsible for hypoxia and dimethyloxalylglycine inhibition | Homo sapiens | D-fructose 6-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Homo sapiens |
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 | - |
Homo sapiens |
More | bifunctional enzyme, cf. EC 2.7.1.105 | Homo sapiens |
PFKFB | - |
Homo sapiens |