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Literature summary for 3.1.3.46 extracted from

  • Donthi, R.V.; Ye, G.; Wu, C.; McClain, D.A.; Lange, A.J.; Epstein, P.N.
    Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity (2004), J. Biol. Chem., 279, 48085-48090.
    View publication on PubMed
Search for more literature for 3.1.3.46

Activating Compound

Activating Compound Comment Organism Structure
additional information the hepatic enzyme expression is stimulated at transcriptional level by both insulin and glucocorticoids Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant PFK-2 in 6-phosphofructo-2-kinase-deficient myocytes Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information cardiac expression of kinase-deficient enzyme in amyocyte cell line inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus metabolic regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 male and female mice
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Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
myocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information metabolic regulation, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Mus musculus
Pfk-2
-
 Mus musculus
PFK-2/Fru-2,6-P2
-
 Mus musculus