Literature summary for 3.1.3.46 extracted from

Minchenko, O.H.; Ochiai, A.; Opentanova, I.L.; Ogura, T.; Minchenko, D.O.; Caro, J.; Komisarenko, S.V.; Esumi, H.
Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors (2005), Biochimie, 87, 1005-1010.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
beta-D-fructose 2,6-bisphosphate + H2O	Homo sapiens	the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level	D-fructose 6-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes PFKFB-4 and PFKFB-3	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	-	Homo sapiens	-
breast carcinoma cell	overexpression of isozyme PFKFB-4 in breast and colon malignant tumors compared to non-malignant tissue, overexpression of isozyme PFKFB-4 is correlated with enhanced expression of isozyme PFKFB-3, hypoxia-inducible factor 1alpha, dependent glucose transporter 1, and vascular endothelial growth factor VEGF, overview	Homo sapiens	-
colon	-	Homo sapiens	-
colonic cancer cell	overexpression of isozyme PFKFB-4 in breast and colon malignant tumors compared to non-malignant tissue, overexpression of isozyme PFKFB-4 is correlated with enhanced expression of isozyme PFKFB-3, hypoxia-inducible factor 1alpha, dependent glucose transporter 1, and vascular endothelial growth factor VEGF, overview	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-D-fructose 2,6-bisphosphate + H2O	-	Homo sapiens	D-fructose 6-phosphate + phosphate	-	?
beta-D-fructose 2,6-bisphosphate + H2O	the bifunctional enzyme is responsible for regulation of intracellular beta-D-fructose 2,6-bisphosphate level	Homo sapiens	D-fructose 6-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase	-	Homo sapiens
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4	-	Homo sapiens
More	bifunctional enzyme, cf. EC 2.7.1.105	Homo sapiens
PFKFB	-	Homo sapiens

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Release 2023.1 (January 2023)