Literature summary for 3.1.3.46 extracted from

Kurland, I.J.; Chapman, B.; El-Maghrabi, M.R.
N- and C-termini modulate the effects of pH and phosphorylation on hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (2000), Biochem. J., 347, 459-467.

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Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of N- and C-terminal amino acids to define the catalytic core and the phosphorylation site of protein kinase A	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, recombinant enzyme, liver and muscle isoform	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation by proteinkinase A at S32 results in reduced affinity for fructose-6-phosphate and stimulates bisphosphatase activity	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	isoform with proteinkinase A phosphorylation site	Rattus norvegicus	-
muscle	isoform lacks proteinkinase A phosphorylation site	Rattus norvegicus	-

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Release 2023.1 (January 2023)