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Literature summary for 3.1.3.43 extracted from

  • Pettit, F.H.; Roche, T.E.; Reed, L.J.
    Function of Calcium ions in pyruvate dehydrogenase phosphatase activity (1972), Biochem. Biophys. Res. Commun., 49, 563-571.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EGTA inhibits binding of the phosphatase to transacetylase Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.029
-
[Pyruvate dehydrogenase (lipoamide)]-phosphate presence of Ca2+ and transacetylase Bos taurus
0.058
-
[Pyruvate dehydrogenase (lipoamide)]-phosphate presence of EGTA and transacetylase Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required to bind the phosphatase to the transacetylase Bos taurus
Mg2+ required Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O Bos taurus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-
kidney
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O presence of EGTA or Ca2+ and transacetylase Bos taurus [pyruvate dehydrogenase (lipoamide)] + phosphate
-
ir
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
Bos taurus ?
-
?