Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NCN5 | pyruvate dehydrogenase phosphatase regulatory subunit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HTR-8/SVneo cell | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of small RNA miR-195 results in enhanced apoptosis, decreased mitochondrial membrane potential and cellular ATP content upon hydrogen peroxide stimulation. The effects can be partially rescued by PDPR or flavin adenine dinucleotide-dependent oxidoreductase domain containing protein FOXRED1. In preeclamptic patients, lowered circulating levels of miR-195 are found at early-to-mid gestation and term pregnancy, and marked increases in FOXRED1 and PDPR expression are observed in the placenta when compared with gestational week-matched controls | Homo sapiens |