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Literature summary for 3.1.3.43 extracted from

  • Wang, H.; Zhang, L.; Guo, X.; Bai, Y.; Li, Y.X.; Sha, J.; Peng, C.; Wang, Y.L.; Liu, M.
    MiR-195 modulates oxidative stress-induced apoptosis and mitochondrial energy production in human trophoblasts via flavin adenine dinucleotide-dependent oxidoreductase domain-containing protein 1 and pyruvate dehydrogenase phosphatase regulatory subunit (2018), J. Hypertens., 36, 306-318 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NCN5 pyruvate dehydrogenase phosphatase regulatory subunit
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Source Tissue

Source Tissue Comment Organism Textmining
HTR-8/SVneo cell
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Homo sapiens
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placenta
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Homo sapiens
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General Information

General Information Comment Organism
physiological function overexpression of small RNA miR-195 results in enhanced apoptosis, decreased mitochondrial membrane potential and cellular ATP content upon hydrogen peroxide stimulation. The effects can be partially rescued by PDPR or flavin adenine dinucleotide-dependent oxidoreductase domain containing protein FOXRED1. In preeclamptic patients, lowered circulating levels of miR-195 are found at early-to-mid gestation and term pregnancy, and marked increases in FOXRED1 and PDPR expression are observed in the placenta when compared with gestational week-matched controls Homo sapiens