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Literature summary for 3.1.3.43 extracted from

  • Kaplon, J.; Zheng, L.; Meissl, K.; Chaneton, B.; Selivanov, V.A.; Mackay, G.; van der Burg, S.H.; Verdegaal, E.M.; Cascante, M.; Shlomi, T.; Gottlieb, E.; Peeper, D.S.
    A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence (2013), Nature, 498, 109-112.
    View publication on PubMed
Search for more literature for 3.1.3.43

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O Homo sapiens
-
 [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O
-
 Homo sapiens [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDP2
-
 Homo sapiens
pyruvate dehydrogenase phosphatase 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens an oncogene BRAFV600E-induced senescence is accompanied by induction of the pyruvate dehydrogenase phosphatase 2 up