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Literature summary for 3.1.3.42 extracted from

  • Thomas, J.A.; Nakai, C.
    Control of glycogen synthase phosphatase from rat heart (1973), J. Biol. Chem., 248, 2208-2213.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ 5 mM, 2.4fold activation Rattus norvegicus
D-glucosamine 6-phosphate 2 mM, 30°C, pH 7.8, 3.2fold activation Rattus norvegicus
D-glucose 1-phosphate 2 mM, 30°C, pH 7.8, 3.8fold activation Rattus norvegicus
D-glucose 6-phosphate 4.9fold activation, without D-glucose 6-phosphate 38.8% remainimng activity and additionally without D-glucose 6-phosphate 23.1% remaining activity Rattus norvegicus
Mg2+ 5 mM, 3.7fold activation, without Mg2+ 33% remaining activity and additionally without D-glucose 6-phosphate 23.1% remaining activity Rattus norvegicus
Mn2+ 5 mM, 4.4fold activation Rattus norvegicus
additional information no effects of 5 mM K+ and Na+, and 2 mM 6-P-gluconate, D-fructose 1,6-bisphosphate, alpha-glycerol phosphate, creatine phosphate, phosphate, and SO42- Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
glycogen competitive inhibition with glycogen synthase D as substrate Rattus norvegicus
KF 50 mM, 30°C, pH 7.8, complete inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoprotein phosphatase + H2O Rattus norvegicus
-
protein + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen synthase D + H2O
-
Rattus norvegicus glycogen synthase I + phosphate
-
?
phosphoprotein phosphatase + H2O
-
Rattus norvegicus protein + phosphate
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase phosphatase
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
at 30°C Rattus norvegicus