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Literature summary for 3.1.3.4 extracted from

  • Touat-Hamici, Z.; Weidmann, H.; Blum, Y.; Proust, C.; Durand, H.; Iannacci, F.; Codoni, V.; Gaignard, P.; Therond, P.; Civelek, M.; Karabina, S.A.; Lusis, A.J.; Cambien, F.; Ninio, E.
    Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function (2016), Cardiovasc. Res., 112, 702-713 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingosine-1-phosphate + H2O Homo sapiens
-
sphingosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14495
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphingosine-1-phosphate + H2O
-
Homo sapiens sphingosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipid phosphate phosphatase 3
-
Homo sapiens
LPP3
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens LPP3 expression is negatively correlated with vascular endothelial growth factor expression down

General Information

General Information Comment Organism
malfunction LPP3 silencing in human primary aortic endothelial cells enhances secretion of inflammatory cytokines, leucocyte adhesion, cell survival, and migration and impairs angiogenesis, whereas wild-type LPP3 overexpression reversed these effects and induces apoptosis Homo sapiens
physiological function LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in human primary aortic endothelial cells, suggesting a protective role of LPP3 against endothelial dysfunction in humans Homo sapiens