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Literature summary for 3.1.3.4 extracted from

  • Ren, H.; Federico, L.; Huang, H.; Sunkara, M.; Drennan, T.; Frohman, M.; Smyth, S.; Morris, A.
    A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis (2010), Mol. Biol. Cell, 21, 3171-3181.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Protein Variants

Protein Variants Comment Organism
D712E catalytically inactive mutant Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
membrane
-
 Mus musculus 16020
-
nucleus the transcriptional coactivator function of lipin1beta necessarily requires localization in the nucleus Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidic acid + H2O Mus musculus
-
 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O
-
 Mus musculus 1,2-diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
lipin1beta
-
 Mus musculus
phosphatidic acid phosphatase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the lipin 1 polybasic motif is critical for lipin1beta function in phospholipid and neutral lipid metabolism. Lipin1beta also functions as transcriptional coactivator. Both the transcriptional and metabolic functions of lipin 1 are required for full complementation of the adipogenic differentiation of lipin-deficient MEF cells. Lipin1 is also an amplifier of PGC-1alpha, a nuclear coactivator of PPAR-alpha responsive gene transcription Mus musculus