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Literature summary for 3.1.3.4 extracted from

  • Koh, Y.K.; Lee, M.Y.; Kim, J.W.; Kim, M.; Moon, J.S.; Lee, Y.J.; Ahn, Y.H.; Kim, K.S.
    Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2 (2008), J. Biol. Chem., 283, 34896-34906.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
full-length lipin1beta cDNA amplified and cloned into the pcDNA3.1-V5/His-TOPO expression vector and pSG5-FLAG-tagged expression vector. Peroxisome proliferator-activated receptor gamma2 and lipin1 overexpressed in NIH3T3 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutation of IL728FF does not affect the interaction with peroxisome proliferator-activated receptor gamma2 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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 Mus musculus
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preadipocyte
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 Mus musculus
-

Synonyms

Synonyms Comment Organism
lipin1alpha
-
 Mus musculus
lipin1beta
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 Mus musculus

Expression

Organism Comment Expression
Homo sapiens lipin1 is induced in the late stages of adipocyte differentiation. During the maturation of adipocytes, the increase of lipin1alpha is less than that of lipin1beta. CCAAT/enhancer-binding protein alpha directly controls the expression of lipin1, overexpression of CCAAT/enhancer-binding protein alpha activates the lipin1 promoter (from nt -1340 to -524) about 6fold over the basal activity in a transient transfection assay up

General Information

General Information Comment Organism
physiological function lipin1 reinforces the positive feedback loop between CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma2, which is essential for adipogenesis and the maintenance of adipocyte functions. Lipin1 is necessary and accelerates 3T3-L1 adipocyte differentiation. Lipin1 maintains the expression of adipocyte functional genes in 3T3-L1 mature adipocytes. Lipin1 functions by interacting with and activating peroxisome proliferator-activated receptor gamma2 Homo sapiens