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Literature summary for 3.1.3.4 extracted from

  • Brindley, D.N.; Pilquil, C.; Sariahmetoglu, M.; Reue, K.
    Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases (2009), Biochim. Biophys. Acta, 1791, 956-961.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ depends on Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell lipin-1 and lipin-2 Mus musculus
-
fibroblast
-
Rattus norvegicus
-
muscle
-
Homo sapiens
-
preadipocyte cell line lipin-2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Mus musculus 1,2-diacyl-sn-glycerol + phosphate
-
?
phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
?
phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
?

Synonyms

Synonyms Comment Organism
lipin-1
-
Mus musculus
lipin-1
-
Homo sapiens
lipin-2
-
Mus musculus
lipin-2
-
Homo sapiens
lipin-3
-
Mus musculus
LPP
-
Mus musculus
LPP
-
Rattus norvegicus
LPP1
-
Homo sapiens
LPP2
-
Homo sapiens
PAP
-
Mus musculus
PAP
-
Homo sapiens
PAP1
-
Rattus norvegicus
phosphatidate phosphatase
-
Mus musculus
phosphatidate phosphatase
-
Homo sapiens
phosphatidate phosphatase
-
Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus in the 3T3-L1 cell line, lipin-2 protein levels decline dramatically as adipocyte differentiation proceeds to become virtually undetectable in mature adipocytes, when lipin-1 is expressed at high levels down
Mus musculus in the 3T3-L1 cell line, lipin-2 protein levels are highest in preadipocytes up

General Information

General Information Comment Organism
malfunction lipin-1 deficiency causes lipodystrophy, neonatal fatty liver, peripheral neuropathy, insulin resistance, and increased susceptibility to atherosclerosis Mus musculus
malfunction lipin-1 deficiency in rare human patients, causes acute myoglobinuria in childhood, does not result in lipodystrophy in these individuals. Muscle sample from a patient with lipin-1 deficiency reveals elevated phosphatidate levels. Rare patients with lipin-2 deficiency have a complex phenotype known as Majeed syndrome, characterized by recurrent osteomyelitis, fever, and anemia Homo sapiens
physiological function activation of fibroblasts by lysophosphatidate causes a translocation of Mg2+-dependent PAP activity to the membrane fraction within 2 min when the production of phosphatidic acid and diacylglycerol is increased by lysophosphatidate and platelet-derived growth factor. Translocations of PAP1 activity probably results from the increased presence of phosphatidic acid in membranes Rattus norvegicus
physiological function key role for lipin-1 in adipocyte differentiation and lipid biosynthesis Mus musculus
physiological function lipin proteins serve an important role in regulating the balance of lipid intermediates, including phosphatidic acid and diacylglycerol, and maintenance of cellular lipid homeostasis Homo sapiens