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Literature summary for 3.1.3.4 extracted from
- Roles of phosphatidate phosphatase enzymes in lipid metabolism (2006), Trends Biochem. Sci., 31, 694-699.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | pah1? mutants show a temperature sensitivity phenotype | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bromoenol lactone | selective inhibition of PAP1 | Saccharomyces cerevisiae |  |
| diacylglycerol | DPP1-encoded PAP2 enzyme is inhibited by CDP-DAG | Saccharomyces cerevisiae | |
| NEM | the yeast DPP1-encoded PAP2 activity is insensitive to NEM, whereas LPP1-encoded PAP2 activity is sensitive to NEM | Saccharomyces cerevisiae | |
| Zn2+ | PAP2 activity is also inhibited by Zn2+ ions in a mechanism that involves the formation of DGPP-Zn2+ complexes | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isozyme PAP1 | Saccharomyces cerevisiae | 5829 | - |
| membrane | isozyme PAP1, PAP2s are integral membrane proteins | Saccharomyces cerevisiae | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Lpp1p contains ten cysteine residues, whereas Dpp1p and Pah1p contain only three | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidic acid + H2O | Saccharomyces cerevisiae | PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate, isozyme PAP1 plays a role in the transcriptional regulation of phospholipid synthesis, overview | 1,2-diacylglycerol + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
isozymes PAP1 and PAP2, encoded by genes PAH1, formerly known as SMP2, and DPP1 and LPP1, respectively | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidic acid + H2O | - |
Saccharomyces cerevisiae | 1,2-diacylglycerol + phosphate | - |
? | |
| phosphatidic acid + H2O | PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate, isozyme PAP1 plays a role in the transcriptional regulation of phospholipid synthesis, overview | Saccharomyces cerevisiae | 1,2-diacylglycerol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | PAP1 enzyme has a DxDxT catalytic motif within a haloacid dehalogenase- like domain, the DPP1-and LPP1-encoded PAP2 enzymes contain a three-domain lipid phosphatase motif that is localized to the hydrophilic surface of the membrane | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-sn-phosphatidate phosphohydrolase | - |
Saccharomyces cerevisiae |
| Dpp1p | - |
Saccharomyces cerevisiae |
| Lpp1p | - |
Saccharomyces cerevisiae |
| Pah1p | - |
Saccharomyces cerevisiae |
| PAP1 | - |
Saccharomyces cerevisiae |
| PAP2 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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