Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | regulation of filopodia by LPR1 is not mediated by cdc42 or Rif, and is independent of the Arp2/3 complex | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
LPP1 and LPR1 expressed in Sf9 cells using a baculovirus vector. Recombinant LPR1 and mutants incorporating a C-terminal EGFP tag expressed in HeLa and COS7 cells. Overexpression of EGFP-LPR1 in SK-OV-3 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | LPR1 variants containing non-conservative substitutions of Ser198 and His200 within the C2 motif and Arg246 from the C3 motif are strongly expressed in transient transfection experiments but fail to induce the formation of filopodia in HeLa cells. In contrast to wild-type LPR1, these mutant LPR1 proteins are exclusively localized to intracellular membranes. LPR1 C-term DELTA43 mutant, is incapable of generating new filopodia, but rather localizes to pre-existing endogenous protrusions extended by these cells. Subcellular distribution of mutant LPR1 C-term DELTA43 between the plasma membrane and intracellular membranes is highly comparable with that of wild-type LPR1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi2 | reduces expression levels of LPR1 by ca. 60% in SK-OV-3 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | LPR1 is predominantly distributed uniformly along shafts of protrusions, with an occasional enrichment at their tips. LPR1 may be an integral membrane protein link between the actin core and the surrounding lipid layer of a nascent filopodium. LPP3 does not show these types of membrane protrusions | Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
LPR1, Western blot analysis | Homo sapiens |
38000 | - |
LPR1, Western blot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TBJ4 | LPR1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
filopodium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide 1-phosphate + H2O | LPP1 but not LPR1 | Homo sapiens | ceramide + phosphate | - |
? | |
lyso-phosphatidic acid + H2O | LPP1 but not LPR1 | Homo sapiens | monoacylglycerol + phosphate | - |
? | |
additional information | LPR1 does not hydrolyze phospholipid substrates under conditions that readily support LPP1 activity | Homo sapiens | ? | - |
? | |
phosphatidic acid + H2O | LPP1 but not LPR1 | Homo sapiens | diacylglycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | LPP1 but not LPR1 | Homo sapiens | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipidphosphatase-related protein 1 | - |
Homo sapiens |
LPP1 | - |
Homo sapiens |
LPP2 | - |
Homo sapiens |
LPP3 | - |
Homo sapiens |
LPR1 | - |
Homo sapiens |
PRG3 | - |
Homo sapiens |