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Literature summary for 3.1.3.4 extracted from
- Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility (2007), Endocrinology, 148, 3685-3693.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | lipin1-deficient mice show reduce fertility, phenotype, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
nondiabetic C57BL6 and CD-1 mice, and diabetic NOD mice and Pd-NOD mice, gene lipin1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| uterus | predominantly in the glandular and luminal epithelium, apical region, overview | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
expression levels in uteri and livers of nondiabetic C57BL6 and CD-1 mice, and diabetic NOD mice and Pd-NOD mice, overview | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview | Mus musculus | ? | - |
? | |
| phosphatidic acid + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Lipin1 | - |
Mus musculus |
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