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Literature summary for 3.1.3.4 extracted from

  • Oshiro, J.; Han, G.S.; Carman, G.M.
    Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae (2003), Biochim. Biophys. Acta, 1635, 1-9.
    View publication on PubMed
Search for more literature for 3.1.3.4

Activating Compound

Activating Compound Comment Organism Structure
additional information expression of the DPP1 gene, which encodes DGPP phosphatase, is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase, induction by zinc depletion is mediated by the transcription factor Zap1p, which binds to a zinc-responsive element in the DPP1 promoter Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
4-chlormercuriphenylsulfonic acid
-
 Saccharomyces cerevisiae
Ca2+
-
 Saccharomyces cerevisiae
Co2+
-
 Saccharomyces cerevisiae
diacylglycerol diphosphate conpetitive versus phosphatidate Saccharomyces cerevisiae
Mn2+
-
 Saccharomyces cerevisiae
NEM potent inhibition of LPP1 Saccharomyces cerevisiae
Phenylglyoxal
-
 Saccharomyces cerevisiae
phosphatidate conpetitive versus diacylglycerol diphosphate Saccharomyces cerevisiae
Zn2+
-
 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
additional information the enzyme is Mg2+-independent and shows no divalent cation requirement for activity Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylglycerol diphosphate + H2O Saccharomyces cerevisiae
-
 phosphatidate + phosphate
-
 ?
phosphatidate + H2O Saccharomyces cerevisiae preferred substrate diacyl-sn-glycerol + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 gene LPP1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylglycerol diphosphate + H2O
-
 Saccharomyces cerevisiae phosphatidate + phosphate
-
 ?
diacylglycerol diphosphate + H2O the bifunctional LPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae phosphatidate + phosphate
-
 ?
lysophosphatidic acid + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
additional information the LPP1-encoded enzyme has broad substrate specificity Saccharomyces cerevisiae ?
-
 ?
phosphatidate + H2O preferred substrate, the bifunctional LPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate
-
 ?
phosphatidate + H2O preferred substrate Saccharomyces cerevisiae diacyl-sn-glycerol + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
More cf. EC 3.1.3.B2, the enzyme is a member of the lipid phosphate phosphatase superfamily Saccharomyces cerevisiae