Cloned (Comment) | Organism |
---|---|
expression of LPP1 in Drosophila melanogaster cells S2 | Mus musculus |
overexpression of LPPs in HEK293 cells, expression of LPP3 in Drosophila melanogaster cells S2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by NEM | Drosophila melanogaster | |
additional information | no inhibition by NEM | Homo sapiens | |
additional information | no inhibition by NEM | Mus musculus | |
additional information | no inhibition by NEM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
caveola | isozymes LPP1 and LPP3 | Mus musculus | 5901 | - |
caveola | isozymes LPP1 and LPP3 | Homo sapiens | 5901 | - |
caveola | isozymes LPP1 and LPP3 | Rattus norvegicus | 5901 | - |
endoplasmic reticulum | isozyme LPP3 | Mus musculus | 5783 | - |
endoplasmic reticulum | isozyme LPP3 | Homo sapiens | 5783 | - |
endoplasmic reticulum | isozyme LPP3 | Rattus norvegicus | 5783 | - |
membrane | integral | Drosophila melanogaster | 16020 | - |
membrane | integral | Mus musculus | 16020 | - |
membrane | integral | Homo sapiens | 16020 | - |
membrane | integral | Rattus norvegicus | 16020 | - |
additional information | the enzyme also hydrolyses extracellularly located substrates | Drosophila melanogaster | - |
- |
additional information | the enzyme also hydrolyses extracellularly located substrates | Mus musculus | - |
- |
additional information | the enzyme also hydrolyses extracellularly located substrates | Homo sapiens | - |
- |
additional information | the enzyme also hydrolyses extracellularly located substrates | Rattus norvegicus | - |
- |
plasma membrane | - |
Drosophila melanogaster | 5886 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no requirement for Mg2+ | Drosophila melanogaster | |
additional information | no requirement for Mg2+ | Mus musculus | |
additional information | no requirement for Mg2+ | Homo sapiens | |
additional information | no requirement for Mg2+ | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | 83000 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? | |
additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? | |
additional information | Rattus norvegicus | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | ? | - |
? | |
additional information | Drosophila melanogaster | Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
Mus musculus | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
Rattus norvegicus | - |
isozymes LPP1-3, several splicing variants of LPP1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Mus musculus |
glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Homo sapiens |
glycoprotein | the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 | Rattus norvegicus |
phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Mus musculus |
phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Homo sapiens |
phosphoprotein | reversible phosphorylation might play a role in enzyme regulation | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
from liver | Rattus norvegicus |
recombinant LPP1 from Drosophila melanogaster cells S2 by immunoaffinity | Mus musculus |
recombinant LPP3 from Drosophila melanogaster cells S2 by immunoaffinity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Rattus norvegicus | - |
brain | isozyme LPP2 | Homo sapiens | - |
embryo | expression pattern of Wun and Wun2 during embryogenesis | Drosophila melanogaster | - |
epithelium | - |
Rattus norvegicus | - |
germ cell | - |
Drosophila melanogaster | - |
gonad | - |
Drosophila melanogaster | - |
hindgut | primordium | Drosophila melanogaster | - |
intestinal epithelium | isozyme LPP3 | Mus musculus | - |
intestinal epithelium | isozyme LPP3 | Homo sapiens | - |
intestinal epithelium | isozyme LPP3 | Rattus norvegicus | - |
kidney | isozyme LPP2 | Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | isozyme LPP2 | Mus musculus | - |
lung | isozyme LPP2 | Mus musculus | - |
mesoderm | - |
Drosophila melanogaster | - |
midgut | - |
Drosophila melanogaster | - |
additional information | expression pattern and translocation of Wun and Wun2 during gut development | Drosophila melanogaster | - |
additional information | isozymes LPP1 and LPP3 show a wide tissue distribution | Mus musculus | - |
additional information | isozymes LPP1 and LPP3 show a wide tissue distribution | Homo sapiens | - |
additional information | the expression of LPP1-3 is reduced upon preadipocyte differentiation to adipocytes | Rattus norvegicus | - |
neuron | PRG-1 is neuron-specific | Mus musculus | - |
neuron | PRG-1 is neuron-specific | Homo sapiens | - |
neuron | PRG-1 is neuron-specific | Rattus norvegicus | - |
pancreas | isozyme LPP2 | Homo sapiens | - |
placenta | isozyme LPP2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide 1-phosphate + H2O | - |
Mus musculus | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
ceramide 1-phosphate + H2O | - |
Rattus norvegicus | ceramide + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Mus musculus | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Homo sapiens | ? | - |
? | |
additional information | LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes | Rattus norvegicus | ? | - |
? | |
additional information | Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes | Drosophila melanogaster | ? | - |
? | |
additional information | substrate specificities of isozymes | Mus musculus | ? | - |
? | |
additional information | substrate specificities of isozymes | Homo sapiens | ? | - |
? | |
additional information | substrate specificities of isozymes | Rattus norvegicus | ? | - |
? | |
phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | homodimer | Mus musculus |
dimer | homodimer | Homo sapiens |
dimer | homodimer | Rattus norvegicus |
dimer | Wunen forms homodimers | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
Dri42 | i.e. isozyme LPP3 | Rattus norvegicus |
lipid phosphate phosphatase | - |
Drosophila melanogaster |
lipid phosphate phosphatase | - |
Mus musculus |
lipid phosphate phosphatase | - |
Homo sapiens |
lipid phosphate phosphatase | - |
Rattus norvegicus |
LPP | - |
Drosophila melanogaster |
LPP | - |
Mus musculus |
LPP | - |
Homo sapiens |
LPP | - |
Rattus norvegicus |
More | the enzyme belongs to the lipid phosphate phosphatase family | Drosophila melanogaster |
More | the enzyme belongs to the lipid phosphate phosphatase family | Mus musculus |
More | the enzyme belongs to the lipid phosphate phosphatase family | Homo sapiens |
More | the enzyme belongs to the lipid phosphate phosphatase family | Rattus norvegicus |
PRG-1 | plasticity-related gene-1 | Mus musculus |
PRG-1 | plasticity-related gene-1 | Homo sapiens |
PRG-1 | plasticity-related gene-1 | Rattus norvegicus |
Wunen | - |
Drosophila melanogaster |
Wunen2 | - |
Drosophila melanogaster |