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Literature summary for 3.1.3.4 extracted from

  • Pyne, S.; Kong, K.C.; Darroch, P.I.
    Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases (2004), Semin. Cell Dev. Biol., 15, 491-501.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of LPP1 in Drosophila melanogaster cells S2 Mus musculus
overexpression of LPPs in HEK293 cells, expression of LPP3 in Drosophila melanogaster cells S2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by NEM Drosophila melanogaster
additional information no inhibition by NEM Homo sapiens
additional information no inhibition by NEM Mus musculus
additional information no inhibition by NEM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
caveola isozymes LPP1 and LPP3 Mus musculus 5901
-
caveola isozymes LPP1 and LPP3 Homo sapiens 5901
-
caveola isozymes LPP1 and LPP3 Rattus norvegicus 5901
-
endoplasmic reticulum isozyme LPP3 Mus musculus 5783
-
endoplasmic reticulum isozyme LPP3 Homo sapiens 5783
-
endoplasmic reticulum isozyme LPP3 Rattus norvegicus 5783
-
membrane integral Drosophila melanogaster 16020
-
membrane integral Mus musculus 16020
-
membrane integral Homo sapiens 16020
-
membrane integral Rattus norvegicus 16020
-
additional information the enzyme also hydrolyses extracellularly located substrates Drosophila melanogaster
-
-
additional information the enzyme also hydrolyses extracellularly located substrates Mus musculus
-
-
additional information the enzyme also hydrolyses extracellularly located substrates Homo sapiens
-
-
additional information the enzyme also hydrolyses extracellularly located substrates Rattus norvegicus
-
-
plasma membrane
-
Drosophila melanogaster 5886
-
plasma membrane
-
Mus musculus 5886
-
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no requirement for Mg2+ Drosophila melanogaster
additional information no requirement for Mg2+ Mus musculus
additional information no requirement for Mg2+ Homo sapiens
additional information no requirement for Mg2+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000 83000
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes ?
-
?
additional information Homo sapiens LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes ?
-
?
additional information Rattus norvegicus LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes ?
-
?
additional information Drosophila melanogaster Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes ?
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
isozymes LPP1-3, several splicing variants of LPP1
-
Mus musculus
-
isozymes LPP1-3, several splicing variants of LPP1
-
Rattus norvegicus
-
isozymes LPP1-3, several splicing variants of LPP1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 Mus musculus
glycoprotein the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 Homo sapiens
glycoprotein the glycosylation is not required for catalytic activity, no glycosylation of PRG-1 Rattus norvegicus
phosphoprotein reversible phosphorylation might play a role in enzyme regulation Mus musculus
phosphoprotein reversible phosphorylation might play a role in enzyme regulation Homo sapiens
phosphoprotein reversible phosphorylation might play a role in enzyme regulation Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
from liver Rattus norvegicus
recombinant LPP1 from Drosophila melanogaster cells S2 by immunoaffinity Mus musculus
recombinant LPP3 from Drosophila melanogaster cells S2 by immunoaffinity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Rattus norvegicus
-
brain isozyme LPP2 Homo sapiens
-
embryo expression pattern of Wun and Wun2 during embryogenesis Drosophila melanogaster
-
epithelium
-
Rattus norvegicus
-
germ cell
-
Drosophila melanogaster
-
gonad
-
Drosophila melanogaster
-
hindgut primordium Drosophila melanogaster
-
intestinal epithelium isozyme LPP3 Mus musculus
-
intestinal epithelium isozyme LPP3 Homo sapiens
-
intestinal epithelium isozyme LPP3 Rattus norvegicus
-
kidney isozyme LPP2 Mus musculus
-
liver
-
Rattus norvegicus
-
liver isozyme LPP2 Mus musculus
-
lung isozyme LPP2 Mus musculus
-
mesoderm
-
Drosophila melanogaster
-
midgut
-
Drosophila melanogaster
-
additional information expression pattern and translocation of Wun and Wun2 during gut development Drosophila melanogaster
-
additional information isozymes LPP1 and LPP3 show a wide tissue distribution Mus musculus
-
additional information isozymes LPP1 and LPP3 show a wide tissue distribution Homo sapiens
-
additional information the expression of LPP1-3 is reduced upon preadipocyte differentiation to adipocytes Rattus norvegicus
-
neuron PRG-1 is neuron-specific Mus musculus
-
neuron PRG-1 is neuron-specific Homo sapiens
-
neuron PRG-1 is neuron-specific Rattus norvegicus
-
pancreas isozyme LPP2 Homo sapiens
-
placenta isozyme LPP2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide 1-phosphate + H2O
-
Mus musculus ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Homo sapiens ceramide + phosphate
-
?
ceramide 1-phosphate + H2O
-
Rattus norvegicus ceramide + phosphate
-
?
lysophosphatidic acid + H2O
-
Mus musculus monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Homo sapiens monoacylglycerol + phosphate
-
?
lysophosphatidic acid + H2O
-
Rattus norvegicus monoacylglycerol + phosphate
-
?
additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Mus musculus ?
-
?
additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Homo sapiens ?
-
?
additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Rattus norvegicus ?
-
?
additional information Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes Drosophila melanogaster ?
-
?
additional information substrate specificities of isozymes Mus musculus ?
-
?
additional information substrate specificities of isozymes Homo sapiens ?
-
?
additional information substrate specificities of isozymes Rattus norvegicus ?
-
?
phosphatidic acid + H2O
-
Mus musculus diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Homo sapiens diacylglycerol + phosphate
-
?
phosphatidic acid + H2O
-
Rattus norvegicus diacylglycerol + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Mus musculus sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Homo sapiens sphingosine + phosphate
-
?
sphingosine 1-phosphate + H2O
-
Rattus norvegicus sphingosine + phosphate
-
?

Subunits

Subunits Comment Organism
dimer homodimer Mus musculus
dimer homodimer Homo sapiens
dimer homodimer Rattus norvegicus
dimer Wunen forms homodimers Drosophila melanogaster

Synonyms

Synonyms Comment Organism
Dri42 i.e. isozyme LPP3 Rattus norvegicus
lipid phosphate phosphatase
-
Drosophila melanogaster
lipid phosphate phosphatase
-
Mus musculus
lipid phosphate phosphatase
-
Homo sapiens
lipid phosphate phosphatase
-
Rattus norvegicus
LPP
-
Drosophila melanogaster
LPP
-
Mus musculus
LPP
-
Homo sapiens
LPP
-
Rattus norvegicus
More the enzyme belongs to the lipid phosphate phosphatase family Drosophila melanogaster
More the enzyme belongs to the lipid phosphate phosphatase family Mus musculus
More the enzyme belongs to the lipid phosphate phosphatase family Homo sapiens
More the enzyme belongs to the lipid phosphate phosphatase family Rattus norvegicus
PRG-1 plasticity-related gene-1 Mus musculus
PRG-1 plasticity-related gene-1 Homo sapiens
PRG-1 plasticity-related gene-1 Rattus norvegicus
Wunen
-
Drosophila melanogaster
Wunen2
-
Drosophila melanogaster