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Literature summary for 3.1.3.4 extracted from

  • Day, C.P.; Burt, A.D.; Brown, A.S.M.; Bennett, M.K.; Farrell, D.J.; James, O.F.W.; Yeaman, S.J.
    Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis (1993), Clin. Sci., 85, 281-287.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
NEM the enzyme from plasma membrane is insensitive to inhibition, the enzyme from cytosol and microsomes is sensitive to NEM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
microsome
-
 Homo sapiens
-
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal Homo sapiens ?
-
 ?
phosphatidic acid + H2O
-
 Homo sapiens 1,2-diacyl-sn-glycerol + phosphate
-
 ?