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Literature summary for 3.1.3.4 extracted from

  • Jamdar, S.C.; Cao, W.F.
    Properties of phosphatidate phosphohydrolase in rat adipose tissue (1994), Biochem. J., 301, 793-799.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dithiodipyridine 9 mM, 90% inhibition of Mg2+-dependent enzyme, 16% inhibition of Mg2+-independent enzyme Rattus norvegicus
4,4'-dithiodipyridine 9.0 mM, 96% inhibition of Mg2+-dependent enzyme, 20% inhibition of Mg2+-independent enzyme Rattus norvegicus
5,5'-dithiobis(2-nitrobenzoic acid) 0.2 mM, 80% inhibition of Mg2+-dependent enzyme, no inhibition of Mg2+-independent enzyme Rattus norvegicus
cystamine dihydrochloride 1 mM, 25% inhibition of Mg2+-dependent enzyme, 8% inhibition of Mg2+-independent enzyme Rattus norvegicus
N,N'-p-phenylenedimaleimide 0.4 mM, 44% inhibition of Mg2+-dependent enzyme, 7% inhibition of Mg2+-independent enzyme Rattus norvegicus
NEM 1 mM, 80% inhibition of Mg2+-dependent enzyme, 10% inhibition of Mg2+-independent enzyme Rattus norvegicus
thimerosal 0.5 mM, 85% inhibition of Mg2+-dependent enzyme, 12% inhibition of Mg2+-independent enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Mg2+-dependent enzyme form is mainly located in cytosol and microsomes Rattus norvegicus 5829
-
microsome Mg2+-dependent enzyme form is mainly located in cytosol and microsomes. The Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes Rattus norvegicus
-
-
mitochondrion the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes Rattus norvegicus 5739
-
plasma membrane the Mg2+-independent enzyme is mainly located in plasma membrane, mitochondria and microsomes Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ adipose tissue contains 2 different enzyme forms: a Mg2+-dependent form and a Mg2+-independent form Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
Rattus norvegicus ?
-
?
phosphatidic acid + H2O
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Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
?