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Literature summary for 3.1.3.4 extracted from
- Partial purification, properties, and subcellular distribution of rat liver phosphatidate phosphatase (1975), J. Biochem., 77, 501-509.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylcholine | stimulation | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| F- | 50 mM, 90% inhibition | Rattus norvegicus | |
| PCMB | 0.05 mM, 90% inhibition | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
phosphatidic acid | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | the largest portion of the activity is localized in the soluble fraction | Rattus norvegicus | 5829 | - |
| lysosome | only 3% of the total activity | Rattus norvegicus | 5764 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
| Mn2+ | slight stimulation | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 165 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-dipalmitoyl-sn-glycerol 3-phosphate + H2O | - |
Rattus norvegicus | 1,2-dipalmitoyl-sn-glycerol + phosphate | - |
? | |
| 1-acyl-sn-glycerol 3-phosphate + H2O | at 9.1% of the activity with phosphatidic acid | Rattus norvegicus | 1-acyl-sn-glycerol + phosphate | - |
? | |
| 5'-AMP + H2O | 8.6% of the activity with phosphatidic acid | Rattus norvegicus | ? | - |
? | |
| ATP + H2O | 7.2% of the activity with phosphatidic acid | Rattus norvegicus | ? | - |
? | |
| Glucose 6-phosphate + H2O | at 5.2% of the activity with phosphatidic acid | Rattus norvegicus | Glucose + phosphate | - |
? | |
| phosphatidic acid + H2O | - |
Rattus norvegicus | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 7.6 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 8.2 | pH 7.2: 76% of maximal activity, pH 8.2: 74% of maximal activity | Rattus norvegicus |
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