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Literature summary for 3.1.3.4 extracted from

  • Jamdar, S.C.; Osborne, L.J.
    Glycerolipid biosynthesis in rat adipose tissue. 11. Effects of polyamines on Mg2+-dependent phosphatidate phosphohydrolase (1983), Biochim. Biophys. Acta, 752, 79-88.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
polyamines activate in presence of Mg2+, no activation in absence of Mg2+ Rattus norvegicus
putrescine activate in presence of Mg2+, no activation in absence of Mg2+. Effective at 2-5 mM Rattus norvegicus
spermidine activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 1 mM Rattus norvegicus
spermine activates in presence of Mg2+, no activation in absence of Mg2+. Effective at 0.5-1 mM, inhibitory at higher concentrations Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
spermine above 1 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.098
-
phosphatidic acid in presence of various polyamines Rattus norvegicus
0.16
-
phosphatidic acid without polyamines Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidic acid + H2O
-
Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
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