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Literature summary for 3.1.3.39 extracted from
- Streptomycin-6-P phosphohydrolase (1975), Methods Enzymol., 43, 465-470.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amino alcohols | - |
Streptomyces bikiniensis | |
| amino alcohols | - |
Streptomyces galbus | |
| amino alcohols | - |
Streptomyces griseocarneus | |
| amino alcohols | - |
Streptomyces griseus | |
| EDTA | - |
Streptomyces bikiniensis |  |
| EDTA | - |
Streptomyces galbus | |
| EDTA | - |
Streptomyces griseocarneus | |
| EDTA | - |
Streptomyces griseus | |
| phosphate | - |
Streptomyces bikiniensis | |
| phosphate | - |
Streptomyces galbus | |
| phosphate | - |
Streptomyces griseocarneus | |
| phosphate | - |
Streptomyces griseus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrostreptomycin 6-phosphate + H2O | Streptomyces bikiniensis | final step in streptomycin biosynthesis | dihydrostreptomycin + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces bikiniensis | - |
ATCC 11062 | - |
| Streptomyces galbus | - |
ATCC 14077 | - |
| Streptomyces griseocarneus | - |
ATCC 12628 | - |
| Streptomyces griseus | - |
ATCC 12475 | - |
| Streptomyces griseus | - |
little or no activity in ATCC 10971 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Streptomyces griseus | - |
| mycelium | - |
Streptomyces bikiniensis | - |
| mycelium | - |
Streptomyces griseocarneus | - |
| mycelium | - |
Streptomyces galbus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrostreptomycin 6-phosphate | - |
Streptomyces griseus | dihydrostreptomycin + phosphate | - |
? | |
| dihydrostreptomycin 6-phosphate | - |
Streptomyces bikiniensis | dihydrostreptomycin + phosphate | - |
? | |
| dihydrostreptomycin 6-phosphate | - |
Streptomyces griseocarneus | dihydrostreptomycin + phosphate | - |
? | |
| dihydrostreptomycin 6-phosphate | - |
Streptomyces galbus | dihydrostreptomycin + phosphate | - |
? | |
| dihydrostreptomycin 6-phosphate + H2O | final step in streptomycin biosynthesis | Streptomyces bikiniensis | dihydrostreptomycin + phosphate | - |
? | |
| ethanolamine phosphate + H2O | - |
Streptomyces griseus | ? | - |
? | |
| ethanolamine phosphate + H2O | - |
Streptomyces bikiniensis | ? | - |
? | |
| ethanolamine phosphate + H2O | - |
Streptomyces griseocarneus | ? | - |
? | |
| ethanolamine phosphate + H2O | - |
Streptomyces galbus | ? | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Streptomyces griseus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Streptomyces bikiniensis | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Streptomyces griseocarneus | p-nitrophenol + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Streptomyces galbus | p-nitrophenol + phosphate | - |
? | |
| streptidine 6-phosphate + H2O | - |
Streptomyces griseus | dihydrostreptomycin + phosphate | - |
? | |
| streptidine 6-phosphate + H2O | - |
Streptomyces bikiniensis | dihydrostreptomycin + phosphate | - |
? | |
| streptidine 6-phosphate + H2O | - |
Streptomyces griseocarneus | dihydrostreptomycin + phosphate | - |
? | |
| streptidine 6-phosphate + H2O | - |
Streptomyces galbus | dihydrostreptomycin + phosphate | - |
? | |
| streptomycin 6-phosphate + H2O | - |
Streptomyces griseus | streptomycin + phosphate | - |
? | |
| streptomycin 6-phosphate + H2O | - |
Streptomyces bikiniensis | streptomycin + phosphate | - |
? | |
| streptomycin 6-phosphate + H2O | - |
Streptomyces griseocarneus | streptomycin + phosphate | - |
? | |
| streptomycin 6-phosphate + H2O | - |
Streptomyces galbus | streptomycin + phosphate | - |
? | |
| streptomycin-3''-phosphate + H2O | - |
Streptomyces griseus | streptomycin + phosphate | - |
? | |
| streptomycin-3''-phosphate + H2O | - |
Streptomyces bikiniensis | streptomycin + phosphate | - |
? | |
| streptomycin-3''-phosphate + H2O | - |
Streptomyces griseocarneus | streptomycin + phosphate | - |
? | |
| streptomycin-3''-phosphate + H2O | - |
Streptomyces galbus | streptomycin + phosphate | - |
? | |
| Tris-phosphate + H2O | - |
Streptomyces griseus | ? | - |
? | |
| Tris-phosphate + H2O | - |
Streptomyces bikiniensis | ? | - |
? | |
| Tris-phosphate + H2O | - |
Streptomyces griseocarneus | ? | - |
? | |
| Tris-phosphate + H2O | - |
Streptomyces galbus | ? | - |
? | |
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