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Literature summary for 3.1.3.36 extracted from

  • Broberg, C.; Zhang, L.; Gonzalez, H.; Laskowski-Arce, M.; Orth, K.
    A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity (2010), Science, 329, 1660-1662.
    View publication on PubMed
Search for more literature for 3.1.3.36

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Vibrio parahaemolyticus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Vibrio parahaemolyticus
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
additional information Vibrio parahaemolyticus VPA0450 is an inositol polyphosphate 5-phosphatase that hydrolyzed the D5 phosphate from the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio parahaemolyticus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Vibrio parahaemolyticus 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
additional information VPA0450 is an inositol polyphosphate 5-phosphatase that hydrolyzed the D5 phosphate from the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate Vibrio parahaemolyticus ?
-
 ?

Subunits

Subunits Comment Organism
More VPA0450 contains five of the six catalytic motifs found in the active site for the family of inositol polyphosphate 5-phosphatases, enzymes that specifically dephosphorylate the D5 phosphate on an inositol ring Vibrio parahaemolyticus

Synonyms

Synonyms Comment Organism
inositol polyphosphate 5-phosphatase
-
 Vibrio parahaemolyticus
IPP5C
-
 Vibrio parahaemolyticus
VPA0450
-
 Vibrio parahaemolyticus

General Information

General Information Comment Organism
additional information VPA0450 contains five of the six catalytic motifs found in the active site for the family of inositol polyphosphate 5-phosphatases, enzymes that specifically dephosphorylate the D5 phosphate on an inositol ring Vibrio parahaemolyticus
physiological function VPA0450 disrupts cytoskeletal binding sites on the inner surface of membranes of human cells and causes plasma membrane blebbing, which compromised membrane integrity and probably contributed to cell death by facilitating lysis. The effector VPA0450 causes cell rounding faster than the parental POR3 strain or the complemented strain during infection of HeLa cells Vibrio parahaemolyticus