Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Danio rerio | 16020 | - |
plasma membrane | - |
Danio rerio | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-4,5-bisphosphate + H2O | Danio rerio | - |
phosphatidylinositol-4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol-4,5-bisphosphate + H2O | - |
Danio rerio | phosphatidylinositol-4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol lipid 5-phosphatase | - |
Danio rerio |
PIP2 5-phosphatase | - |
Danio rerio |
voltage-sensitive 5-phosphatase | - |
Danio rerio |
VSP | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
malfunction | plasma membrane phosphatidylinositol-4,5-bisphosphate depletion by rapamycin-induced translocation of an inositol lipid 5-phosphatase or by a voltage-sensitive 5-phosphatase suppresses CaV1.2 and CaV1.3 channel currents by about 35% and CaV2.1 and CaV2.2 currents by 29% and 55%, respectively, mechanism, detailed overview. Other CaV channels are less sensitive. Inhibition of CaV channels by Dr-VSP is not simple voltage-dependent inhibition. Phosphatidylinositol-4,5-bisphosphate-dependent modulation of CaV2.2 channels and recovery requiring ATP and phosphatidylinositol-4,5-bisphosphate resynthesis, overview | Danio rerio |