Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of the enzyme in HeLa cells by RNAi | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | preferred substrate | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | preferred substrate | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OCRL phosphatase | - |
Homo sapiens |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase | - |
Homo sapiens |
PtdIns(4;5)P2 5-phosphatase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the phosphatidylinositol-4,5-bisphosphate 5-phosphatase OCRL is mutated in Lowe syndrome patients. Depletion of Rab35 or OCRL inhibits cytokinesis abscission and is associated with local abnormal PtdIns(4;5)P2 and F-actin accumulation in the intercellular bridge, pleiotropic phenotypes associated with Lowe disease, overview | Homo sapiens |
additional information | GTP-bound, active Rab35 directly interacts with OCRL and controls its localization at the intercellular bridge | Homo sapiens |
physiological function | the phosphatidylinositol-4,5-bisphosphate 5-phosphatase OCRL is a downstream effector of the Rab35 GTPase in cytokinesis abscission. PtdIns(4;5)P2 hydrolysis is important for normal cytokinesis abscission to locally remodel the F-actin cytoskeleton in the intercellular bridge, role for the phosphatase OCRL in cell division | Homo sapiens |