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Literature summary for 3.1.3.36 extracted from

  • Soeda, Y.; Tsuneki, H.; Muranaka, H.; Mori, N.; Hosoh, S.; Ichihara, Y.; Kagawa, S.; Wang, X.; Toyooka, N.; Takamura, Y.; Uwano, T.; Nishijo, H.; Wada, T.; Sasaoka, T.
    The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain (2010), Mol. Endocrinol., 24, 1965-1977.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information transgenic mice overexpressing SHIP2 show increased amounts of SHIP2 inducing the disruption of insulin/IGF-I signaling through Akt. Neuroprotective effects of insulin and IGF-I are significantly attenuated in cultured cerebellar granule neurons from SHIP2 transgenic mice, the number of apoptosis-positive cells is increased in cerebral cortex of the transgenic mice at an elderly age, phenotype, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q6P549
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Mus musculus C57/BL6J Q6P549
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Source Tissue

Source Tissue Comment Organism Textmining
brain widely expressed in adult mouse brain. SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice, semiquantitative RT-PCR expression analysis Mus musculus
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neuron
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Mus musculus
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Synonyms

Synonyms Comment Organism
inositol phosphatase
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Mus musculus
SH2-containing inositol 5'-phosphatase 2
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Mus musculus
SHIP2
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Mus musculus

Expression

Organism Comment Expression
Mus musculus SHIP2 mRNA and protein expression levels are significantly increased in the brain of type 2 diabetic db/db mice up

General Information

General Information Comment Organism
malfunction excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin resistance with type 2 diabetes. A dominant-negative mutant of SHIP2, expressed in cultured neurons, causes insulin signaling augmentation. Inhibition of SHIP2 ameliorates the impairment of hippocampal synaptic plasticity and memory formation in db/db mice Mus musculus
physiological function SH2-containing inositol 5'-phosphatase 2, i.e. SHIP2, is a negative regulator of phosphatidylinositol 3,4,5-trisphosphate-mediated signals and shows physiological significance in neurons Mus musculus