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Literature summary for 3.1.3.36 extracted from

  • Deng, X.; Feng, C.; Wang, E.H.; Zhu, Y.Q.; Cui, C.; Zong, Z.H.; Li, G.S.; Liu, C.; Meng, J.; Yu, B.Z.
    Influence of proline-rich inositol polyphosphate 5-phosphatase, on early development of fertilized mouse eggs, via inhibition of phosphorylation of Akt (2011), Cell Prolif., 44, 156-165.
    View publication on PubMed
Search for more literature for 3.1.3.36

Cloned(Commentary)

Cloned (Comment) Organism
from oocytes and fertilized eggs, recombinant overexpression of FLAG-tagged proline-rich inositol polyphosphate 5-phosphatase in eggs Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of FLAG-tagged proline-rich inositol polyphosphate 5-phosphatase in eggs affects localization of phosphorylated Akt at Ser473, egg cell division, MPF activity, and dephosphorylation of cdc2 at Tyr15 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Mus musculus
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Mus musculus Kunming
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Mus musculus
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Mus musculus Kunming
-
 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Kunming
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
egg fertilized Mus musculus
-
oocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Mus musculus Kunming 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Mus musculus Kunming 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PIPP
-
 Mus musculus
proline-rich inositol polyphosphate 5-phosphatase
-
 Mus musculus

General Information

General Information Comment Organism
metabolism proline-rich inositol polyphosphate 5-phosphatase is one of the signal-modifying enzymes that play pivotal regulatory roles in PI3K signalling pathway Mus musculus
physiological function role of proline-rich inositol polyphosphate 5-phosphatase in early development of fertilized mouse eggs, via inhibition of Akt activity through inhibition of Akt phosphorylation at Ser473 and subsequent downstream signalling events Mus musculus