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Literature summary for 3.1.3.36 extracted from

  • Bakowski, M.A.; Braun, V.; Lam, G.Y.; Yeung, T.; Heo, W.D.; Meyer, T.; Finlay, B.B.; Grinstein, S.; Brumell, J.H.
    The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole (2010), Cell Host Microbe, 7, 453-462.
    View publication on PubMed
Search for more literature for 3.1.3.36

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Salmonella enterica
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 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
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 serovar typhimurium
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Salmonella enterica 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
phosphoinositide phosphatase
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 Salmonella enterica
SopB
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 Salmonella enterica

General Information

General Information Comment Organism
malfunction inducible reduction of negative charge rescues DELTAsopB bacteria-containing Salmonella-containing vacuoles from fusion with lysosomes Salmonella enterica
additional information Salmonella typhimurium uses a membrane-charge based mechanism to control Salmonella-containing vacuole maturation Salmonella enterica
physiological function the bacterial phosphoinositide phosphatase SopB is a phosphoinositide phosphatase that, by dephosphorylation of phosphatidylinositol-4,5-bisphosphate at the plasma membrane, contributes to invasion and nascent Salmonella-containing vacuole biogenesis, and controls membrane surface charge of nascent Salmonella-containing vacuoles by reducing levels of negatively charged lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine. This SopB activity results in dissociation of a number of hostcell endocytic trafficking proteins from this compartment and inhibits Salmonella-containing vacuole-lysosome fusion, mechanism, overview. SopB is required for efficient sealing of the Salmonella-containing vacuole membrane during invasion. SopB alters Rab protein recruitment to phagosomes Salmonella enterica