Application | Comment | Organism |
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molecular biology | c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation. Furthermore, SHIP2 positively regulates the tyrosine phosphorylation of JIP1. By its interacting properties, SHIP2 can modulate JIP1-mediated JNK pathway signaling | Homo sapiens |
Cloned (Comment) | Organism |
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expressed in COS-7 cells and in Saccharomyces cerevisiae | Homo sapiens |
Protein Variants | Comment | Organism |
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DELTA1-885/1186-1258 | the effects of SHIP2 on c-Jun NH2-terminal kinase (JNK) activity and JIP1 (JNK-interacting protein 1) tyrosine phosphorylation are independent of the SHIP2 phosphoinositide 5-phosphatase activity, as similar results are obtained when using a SHIP2 catalytic inactive mutant instead of wild-type SHIP2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SHIP2 | - |
Homo sapiens |