Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.36 extracted from

  • Xie, J.; Onnockx, S.; Vandenbroere, I.; Degraef, C.; Erneux, C.; Pirson, I.
    The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity (2008), Cell. Signal., 20, 1432-1441.
    View publication on PubMed

Application

Application Comment Organism
molecular biology c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation. Furthermore, SHIP2 positively regulates the tyrosine phosphorylation of JIP1. By its interacting properties, SHIP2 can modulate JIP1-mediated JNK pathway signaling Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells and in Saccharomyces cerevisiae Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTA1-885/1186-1258 the effects of SHIP2 on c-Jun NH2-terminal kinase (JNK) activity and JIP1 (JNK-interacting protein 1) tyrosine phosphorylation are independent of the SHIP2 phosphoinositide 5-phosphatase activity, as similar results are obtained when using a SHIP2 catalytic inactive mutant instead of wild-type SHIP2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information c-Jun NH2-terminal kinase (JNK)-interacting protein 1 (JIP1) interacts with SHIP2 and thereby positively modulates the MLK3/JIP1-mediated JNK1 activation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
SHIP2
-
Homo sapiens