Literature summary for 3.1.3.36 extracted from

Loovers, H.M.; Kortholt, A.; de Groote, H.; Whitty, L.; Nussbaum, R.L.; van Haastert, P.J.
Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4 (2007), Traffic, 8, 618-628.

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Protein Variants

Protein Variants	Comment	Organism
D319A	inactive mutant bearing a mutation in 5-phosphatase catalytic domain. This mutant is not able to restore dd5p4-null cells	Dictyostelium discoideum
DELTARhoGAPDd5P4	transfection of dd5p4-null cells with a truncated Dd5P4 lacking the C-terminal RhoGAP domain does not restore endocytic defects, suggesting that the C-terminal RhoGAP domain is essential	Dictyostelium discoideum
additional information	expression of the human homolog OCRL (oculocerebrorenal syndrome of Lowe) in Dictyostelium discoideum dd5p4-null cells shows that expression of OCRL largely restores phagocytosis, growth and developmental defects of dd5p4-null cells, indicating that human OCRL can functionally replace Dictyostelium Dd5P4	Dictyostelium discoideum

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	-	-	-

Synonyms

Synonyms	Comment	Organism
Dd5P4	-	Dictyostelium discoideum

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Release 2023.1 (January 2023)