Literature summary for 3.1.3.36 extracted from

Leung, W.H.; Bolland, S.
The inositol 5-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production (2007), J. Immunol., 179, 95-102.

Search for more literature for 3.1.3.36

Protein Variants

Protein Variants	Comment	Organism
additional information	SHIP-2 gene is knockdown in bone marrow-derived mast cells (BMMCs) by using the lentiviral-based RNA interference technique. Elimination results in both increased mast cell degranulation and cytokine (IL-4 and IL-13) gene expression upon FcepsilonRI stimulation. Absence of SHIP-2 results in increased activation of the small GTPase Rac-1 and in enhanced microtubule polymerization upon FcepsilonRI engagement	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
inositol 5'-phosphatase SHIP-2	-	Mus musculus
SH2-domain containing inositol 5'-phosphatase	-	Mus musculus
SHIP2	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)