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Literature summary for 3.1.3.36 extracted from

  • Bertelli, D.F.; Araujo, E.P.; Cesquini, M.; Stoppa, G.R.; Gasparotto-Contessotto, M.; Toyama, M.H.; Felix, J.V.; Carvalheira, J.B.; Michelini, L.C.; Chiavegatto, S.; Boschero, A.C.; Saad, M.J.; Lopes-Cendes, I.; Velloso, L.A.
    Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight (2006), Endocrinology, 147, 5385-5399.
    View publication on PubMed
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Application

Application Comment Organism
medicine inhibition of hypothalamic 5ptase IV expression by this antisense approach results in reduced daily food intake and body weight loss. 5ptase IV is a powerful regulator of signaling through PI3-kinase in hypothalamus and may become an interesting target for therapeutics of obesity and related disorders Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein upon intracerebroventricular treatment with insulin, 5ptase IV undergoes a time-dependent tyrosine phosphorylation. Treatment with a phosphorthioate-modified antisense oligonucleotide for 5ptase IV shows a 70% reduction of insulin induced tyrosine phosphorylation of 5ptase IV and an increase in basal accumulation of phosphorylated inositols in the hypothalamus Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hypothalamus highly expressed in neurons of the arcuate and lateral nuclei of the hypothalamus. Treatment with a phosphorthioate-modified antisense oligonucleotide for 5ptase IV reduces the hypothalamic expression of 5ptase IV by approximately 80% Rattus norvegicus
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Synonyms

Synonyms Comment Organism
5ptase IV
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 Rattus norvegicus
phosphoinositide-specific inositol polyphosphate 5-phosphatase IV
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 Rattus norvegicus