Literature summary for 3.1.3.36 extracted from

Zhang, J.; Liu, Z.; Rasschaert, J.; Blero, D.; Deneubourg, L.; Schurmans, S.; Erneux, C.; Pesesse, X.
SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress (2007), Cell. Signal., 19, 2194-2200.

Search for more literature for 3.1.3.36

Application

Application	Comment	Organism
molecular biology	SHIP2 lipid phosphatase activity plays an important role in the metabolism of PtdIns(3,4,5)P3 in response to H2O2	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	in SHIP2 deficient mouse embryonic fibroblasts (MEFs) stimulated by H2O2 at 15 min, PtdIns(3,4,5)P3 is increased as compared to +/+ cells. No significant increase in PtdIns(3,4)P2 can be detected at 15 or 120 min incubation of the cells with H2O2 (0.6 mM). PKB activity is also upregulated in SHIP2 -/- cells as compared to +/+ cells in response to H2O2	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
inositol 5-phosphatase SHIP2	-	Mus musculus
SHIP2	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)