Literature summary for 3.1.3.36 extracted from

Vandeput, F.; Backers, K.; Villeret, V.; Pesesse, X.; Erneux, C.
The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity (2006), Cell. Signal., 18, 2193-2199.

Search for more literature for 3.1.3.36

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	in contrast to phosphatidylserine SH2 domain containing inositol 5-phosphatase 2 (SHIP2) no stimulation by phosphatidylserine (PtdSer)	Homo sapiens
phosphatidylcholine	vesicles of phosphatidylcholine only stimulate SHIP2 activity by 2fold. This effect is specific for di-C8 and di-C16 fatty acids of D-myo-phosphatidylinositol 3,4,5-trisphosphate as substrate	Homo sapiens
phosphatidylserine	vesicles of phosphatidylserine (PtdSer) greatly stimulate SHIP2. This effect is specific for di-C8 and di-C16 fatty acids of D-myo-phosphatidylinositol 3,4,5-trisphosphate as substrate	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli as a GST-tagged protein	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a minimal catalytic construct D421-T730 is also sensitive to stimulation by phosphatidylserine	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Homo sapiens	-
skeletal muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1D-myo-inositol 1,3,4,5-tetrasphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,3,4-trisphosphate + phosphate	-	?
D-myo-phosphatidylinositol 3,4,5-trisphosphate	reaction is not stimulated by phosphatidylserine	Homo sapiens	D-myo-phosphatidylinositol 3,4-bisphosphate + phosphate	-	?
D-myo-phosphatidylinositol 3,4,5-trisphosphate	reaction is strongly stimulated by phosphatidylserine	Homo sapiens	D-myo-phosphatidylinositol 3,4-bisphosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
SH2 domain containing inositol 5-phosphatase 2	-	Homo sapiens
SHIP2	-	Homo sapiens
skeletal muscle and kidney enriched inositol phosphatase	-	Homo sapiens
SKIP	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)