Literature summary for 3.1.3.36 extracted from

Morales-Johansson, H.; Jenoe, P.; Cooke, F.T.; Hall, M.N.
Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4 (2004), J. Biol. Chem., 279, 39604-39610.

Search for more literature for 3.1.3.36

Activating Compound

Activating Compound	Comment	Organism	Structure
IRS4	binds and activates the enzyme INP51, acts as a negative regulator for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate contents, IRS4 contains an EPS15 homology domain, interaction analysis	Saccharomyces cerevisiae
TAX4	binds and activates the enzyme INP51, acts as a negative regulator for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate contents, TAX4 contains an EPS15 homology domain, interaction analysis	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
expression of tagged enzyme	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	Saccharomyces cerevisiae	the enzyme is involved in regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels, an important second messenger in signalling pathways, e.g. MAP kinase activation, enzyme regulation by effectors TAX4 and IRS4, overview	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	Saccharomyces cerevisiae TB50	the enzyme is involved in regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels, an important second messenger in signalling pathways, e.g. MAP kinase activation, enzyme regulation by effectors TAX4 and IRS4, overview	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	and isogenic derivatives	-
Saccharomyces cerevisiae TB50	-	and isogenic derivatives	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant tagged enzyme	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Saccharomyces cerevisiae	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	the enzyme is involved in regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels, an important second messenger in signalling pathways, e.g. MAP kinase activation, enzyme regulation by effectors TAX4 and IRS4, overview	Saccharomyces cerevisiae	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	-	Saccharomyces cerevisiae TB50	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O	the enzyme is involved in regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate levels, an important second messenger in signalling pathways, e.g. MAP kinase activation, enzyme regulation by effectors TAX4 and IRS4, overview	Saccharomyces cerevisiae TB50	1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
INP51	-	Saccharomyces cerevisiae
PI(4,5)P2 5-phosphatase	-	Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)