Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence detremination and analysis, expression of GFP-tagged synaptojanin-1 in CHO cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
additional information | the enzyme reduces the Ca2+ flux in the cell | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | synaptojanin-1 regulates of turnover of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pool involved Ca2+ signalling and in clathrin and actin dynamics at the cell surface, SJ-1 attenuates the oscillations of Ca2+ induced by ATP and the catalytic domain of its 5-Pase domain mimicking the effect, overview | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | synaptojanin-1 regulates of turnover of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate pool involved Ca2+ signalling and in clathrin and actin dynamics at the cell surface, SJ-1 attenuates the oscillations of Ca2+ induced by ATP and the catalytic domain of its 5-Pase domain mimicking the effect, overview | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? | |
7-nitrobenz-2-oxa-1,3-diazole 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | fluorescence-labeled substrate | Homo sapiens | 7-nitrobenz-2-oxa-1,3-diazole 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphoinositide phosphatase | - |
Homo sapiens |
PtdIns(4,5)P2 phosphatase | - |
Homo sapiens |
SJ-1 | - |
Homo sapiens |
synaptojanin-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |