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Literature summary for 3.1.3.36 extracted from

  • Zhang, X.; Hartz, P.A.; Philip, E.; Racusen, L.C.; Majerus, P.W.
    Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate (1998), J. Biol. Chem., 273, 1574-1582.
    View publication on PubMed
Search for more literature for 3.1.3.36

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 Inositol 1,3,4,5-tetrakisphosphate
-
 Homo sapiens
0.123
-
 Inositol 1,4,5-trisphosphate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome enzyme is associated with the lysosomal membrane Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the X-chromosome encoded enzyme is deficient in oculocerebrorenal syndrome ?
-
 ?
additional information Homo sapiens the enzyme may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-diphosphate that is associated with lysosomes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cell line cell lines from kidney proximal tubules of a patient with Lowe syndrome and a normal individual Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens inositol 1,3,4-trisphosphate + phosphate
-
 ?
additional information the X-chromosome encoded enzyme is deficient in oculocerebrorenal syndrome Homo sapiens ?
-
 ?
additional information the enzyme may function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-diphosphate that is associated with lysosomes Homo sapiens ?
-
 ?
myo-inositol 1,4,5-trisphosphate + H2O
-
 Homo sapiens inositol 1,4-diphosphate + phosphate
-
 ?
myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens ?
-
 ?
phosphatidyl-myo-inositol 4,5-bisphosphate + H2O
-
 Homo sapiens phosphatidylinositol 4-phosphate + phosphate
-
 ?