BRENDA - Enzyme Database
show all sequences of 3.1.3.35

Involvement of a substrate cycle between thymidine and thymidylate in the regulation of DNA precursor pool in Ehrlich ascites tumor

He, Q.; Skog, S.; Cell. Physiol. Biochem. 12, 305-314 (2002)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
73.39
-
dTMP
pH 7.5, 37C, exponentially growing cells
Mus musculus
1267
-
dTMP
pH 7.5, 37C, stationary phase cells
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Mus musculus
substrate cycle between thymidine and thymidylate in exponentially growing cells, regulation of enzyme
?
-
Mus musculus
?
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
dTMP + H2O
-
650791
Mus musculus
thymidine + phosphate
-
650791
Mus musculus
?
additional information
substrate cycle between thymidine and thymidylate in exponentially growing cells, regulation of enzyme
650791
Mus musculus
?
-
650791
Mus musculus
?
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
73.39
-
dTMP
pH 7.5, 37C, exponentially growing cells
Mus musculus
1267
-
dTMP
pH 7.5, 37C, stationary phase cells
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
additional information
Mus musculus
substrate cycle between thymidine and thymidylate in exponentially growing cells, regulation of enzyme
?
-
Mus musculus
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Ehrlich ascites carcinoma cell
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
dTMP + H2O
-
650791
Mus musculus
thymidine + phosphate
-
650791
Mus musculus
?
additional information
substrate cycle between thymidine and thymidylate in exponentially growing cells, regulation of enzyme
650791
Mus musculus
?
-
650791
Mus musculus
?
Other publictions for EC 3.1.3.35
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
650698
Lee
Overproduction of thymidine by ...
Bacillus phage PBS2
Biotechnol. Lett.
26
265-268
2004
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1
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650791
He
Involvement of a substrate cyc ...
Mus musculus
Cell. Physiol. Biochem.
12
305-314
2002
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2
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1
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1
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1
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2
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652211
Cook
The delta subunit of type 6 ph ...
Bos taurus, Bos taurus PDE6
J. Biol. Chem.
276
5248-5255
2001
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1
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3
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1
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1
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81088
Fisher
Isozyme phenotypes of polyoma ...
Mus musculus
Cancer Res.
43
3783-3792
1983
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1
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1
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81087
Schaer
Thymidine nucleotide synthesis ...
Cricetulus griseus
Biochim. Biophys. Acta
697
221-228
1982
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-
-
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1
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1
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1
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1
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1
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1
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1
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81085
Price
Deoxythymidylate phosphohydrol ...
Bacillus subtilis
Methods Enzymol.
51
285-290
1978
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-
-
-
-
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2
2
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3
1
1
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2
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1
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1
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4
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1
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1
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1
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2
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2
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3
1
1
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1
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1
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4
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1
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1
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1
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81086
Price
Deoxythymidylate phosphohydrol ...
Bacillus subtilis
J. Biol. Chem.
248
1372-1380
1973
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9
2
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1
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3
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1
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1
11
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2
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1
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1
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1
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9
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2
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1
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1
11
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2
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1
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1
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1
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81084
Vasken Aposhian
Deoxythymidylate 5-nucleotidas ...
Bacillus subtilis
J. Biol. Chem.
241
5095-5101
1966
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4
3
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2
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3
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1
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4
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1
1
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4
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3
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2
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1
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4
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1
1
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