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Literature summary for 3.1.3.32 extracted from

  • Della-Maria, J.; Hegde, M.L.; McNeill, D.R.; Matsumoto, Y.; Tsai, M.S.; Ellenberger, T.; Wilson, D.M.; Mitra, S.; Tomkinson, A.E.
    The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites (2012), J. Biol. Chem., 287, 39233-39244.
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000179
-
 3'-phospho-5'-hydroxy-DNA at pH 7.5 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phospho-5'-hydroxy-DNA + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phospho-5'-hydroxy-DNA + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PNKP
-
 Homo sapiens
polynucleotide kinase 3'-phosphatase
-
 Homo sapiens
polynucleotide kinase phosphatase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.42
-
 3'-phospho-5'-hydroxy-DNA at pH 7.5 and 37°C Homo sapiens

General Information

General Information Comment Organism
metabolism interaction between XRCC1 and polynucleotide kinase 3'-phosphatase is critical for the retention of XRCC1 at DNA damage sites and DNA damage repair Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
23330
-
 3'-phospho-5'-hydroxy-DNA at pH 7.5 and 37°C Homo sapiens