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Literature summary for 3.1.3.26 extracted from

  • Chu, H.M.; Guo, R.T.; Lin, T.W.; Chou, C.C.; Shr, H.L.; Lai, H.L.; Tang, T.Y.; Cheng, K.J.; Selinger, B.L.; Wang, A.H.
    Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis (2004), Structure, 12, 2015-2024.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
phytase in complex with persulfated phytate, determination of three different structures from three crystal forms: phytase alone, phytase bound with myo-inositol hexasulfate at a location slightly away from the active site and phytase bound with myo-inositol hexosulfate at the active site. The crystal structures reveal a phytase fold of the dual-specificity phosphatase type. The active site is locatewd near a conserved Cys241-containing P loop. The enzyme may be a 3-phytase, EC 3.1.3.8, or a 6-phytase, EC 3.1.3.26. The product of the hydrolysis of myo-inositol hexakisphosphate i.e. myo-inositol 1,2,3,4,5-pentakisphosphate or myo-inositol 1,3,4,5,6-pentakisphosphate has not been identified Selenomonas ruminantium

Inhibitors

Inhibitors Comment Organism Structure
myo-inositol hexasulfate the enzyme may be a 3-phytase, EC 3.1.3.8, or a 6-phytase, EC 3.1.3.26. The product of the hydrolysis of myo-inositol hexakisphosphate i.e. myo-inositol 1,2,3,4,5-pentakisphosphate or myo-inositol 1,3,4,5,6-pentakisphosphate has not been identified Selenomonas ruminantium

Organism

Organism UniProt Comment Textmining
Selenomonas ruminantium
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The enzyme may be a 3-phytase (EC 3.1.3.8), or a 4-phytase (synonym 6-phytase, EC 3.1.3.26). The product of the hydrolysis of myo-inositol hexakisphosphate to 1D-myo-inositol 1,2,4,5,6-pentakisphosphate or alternatively 1D-myo-inositol 1,2,3,5,6-pentakisphosphate has not been identified.
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