Any feedback?
Literature summary for 3.1.3.25 extracted from
- Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1 (2007), J. Biol. Chem., 282, 637-646.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D104N | IMPA2 mutant, no activity | Mus musculus |
| D93N | IMPA1 mutant, no activity | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Li+ | - |
Mus musculus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Mus musculus | |
| additional information | the enzyme shows weaker or almost no activity when Mg2+ is replaced by Ca2+, Mn2+, Na+, or K+ (2 mM each) | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | - |
SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O55023 | IMPA1 | - |
| Mus musculus | Q91UZ5 | IMPA2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain cortex | - |
Mus musculus | - |
| cerebellum | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| olfactory bulb | - |
Mus musculus | - |
| pancreas | - |
Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-glucose 1-phosphate | IMPA1 shows intermediate activity towards alpha-D-glucose 1-phosphate, whereas IMPA2 shows significantly lower affinity | Mus musculus | alpha-D-glucose + phosphate | - |
? | |
| D-myo-inositol 1-phosphate + H2O | IMPA1 shows strong activity towards D-myo-inositol 1-phosphate, whereas IMPA2 shows significantly lower affinity | Mus musculus | D-myo-inositol + phosphate | - |
? | |
| scyllo-inositol 1-phosphate + H2O | IMPA1 shows strong activity towards scyllo-inositol 1-phosphate, whereas IMPA2 shows almost no affinity | Mus musculus | scyllo-inositol + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | x-ray crystallography | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IMPA1 | - |
Mus musculus |
| IMPA2 | - |
Mus musculus |
| IMPase | - |
Mus musculus |
| myo-inositol monophosphatase | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | IMPA1 | Mus musculus |
| 7.5 | 8 | IMPA2 | Mus musculus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
the activity of IMPA1 drops to 30% at pH 8.0 | Mus musculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.7 | - |
IMPA1, in the presence of 2 mM MgCl2 | Mus musculus | Li+ | |
| 25 | - |
IMPA2, in the presence of 2 mM MgCl2 | Mus musculus | Li+ | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
