Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.2 extracted from

  • Sun, P.; Sleat, D.E.; Lecocq, M.; Hayman, A.R.; Jadot, M.; Lobel, P.
    Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins (2008), Proc. Natl. Acad. Sci. USA, 105, 16590-16595.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
molecular biology ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information analysis of ACP5-deficient mice reveals that levels of mannose 6-phosphate glycoproteins are highly elevated in tissues that normally express ACP5, and this results from a failure to dephosphorylate lysosomal proteins Mus musculus
additional information overexpression of ACP5 in N1E-115 neuroblastoma cells leads to an increased dephosphorylation of mannose 6-phosphate glycoproteins Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q05117
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
neuroblastoma cell line N1E-115 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mannose 6-phosphate glycoprotein + H2O
-
Mus musculus ?
-
?
additional information ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
acid phosphatase 5
-
Mus musculus
Acp5
-
Mus musculus