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Literature summary for 3.1.3.2 extracted from
- Purification and characterization of a new human prostatic acid phosphatase isoenzyme (1983), Biochemistry, 22, 1055-1062.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | isoenzyme PAP-II is inhibited, isoenzyme PAP-I is not inhibited | Homo sapiens |  |
| F- | - |
Homo sapiens | |
| Fe2+ | isoenzyme PAP-II is inhibited, isoenzyme PAP-I is not inhibited | Homo sapiens | |
| La3+ | isoenzyme PAP-II is inhibited, isoenzyme PAP-I is not inhibited | Homo sapiens | |
| Tartrate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.092 | - |
Alpha-naphthyl phosphate | isoenzyme PAP-I | Homo sapiens | |
| 0.13 | - |
Alpha-naphthyl phosphate | isoenzyme PAP-II | Homo sapiens | |
| 0.47 | - |
p-nitrophenyl phosphate | isoenzyme PAP-I | Homo sapiens | |
| 0.53 | - |
thymolphthalein monophosphate | isoenzyme PAP-I | Homo sapiens | |
| 0.54 | - |
p-nitrophenyl phosphate | isoenzyme PAP-II | Homo sapiens | |
| 1.1 | - |
thymolphthalein monophosphate | isoenzyme PAP-II | Homo sapiens | |
| 1.5 | - |
GMP | isoenzyme PAP-II | Homo sapiens | |
| 2.9 | - |
2-glycerophosphate | isoenzyme PAP-II | Homo sapiens | |
| 3.3 | - |
GMP | isoenzyme PAP-I | Homo sapiens | |
| 4 | - |
phosphorylcholine | isoenzyme PAP-I | Homo sapiens | |
| 10 | - |
2-glycerophosphate | isoenzyme PAP-I | Homo sapiens | |
| 10 | - |
phosphorylcholine | isoenzyme PAP-II | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000, isoenzyme PAP-II, SDS-PAGE | Homo sapiens |
| 120000 | - |
isoenzyme PAP-II, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isoenzyme A, B and C 103 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| prostate gland | isoenzyme PAP-I and PAP-II | Homo sapiens | - |
| prostate gland | carcinoma prostate, benign prostate hypertrophy, normal prostate | Homo sapiens | - |
| seminal plasma | isoenzyme PAP-II | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthyl phosphate + H2O | - |
Homo sapiens | 1-naphthol + phosphate | - |
? | |
| 2-glycerophosphate + H2O | - |
Homo sapiens | glycerol + phosphate | - |
? | |
| GMP + H2O | - |
Homo sapiens | guanosine + phosphate | - |
? | |
| p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? | |
| phosphocholine + H2O | - |
Homo sapiens | choline + phosphate | - |
? | |
| thymolphthalein monophosphate + H2O | - |
Homo sapiens | thymolphthalein + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| monomer | 2 * 55000, isoenzyme PAP-II, SDS-PAGE | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
90 min, isoenzyme PAP-I and PAP-II, 40% loss of activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
isoenzyme PAP-I | Homo sapiens |
| 6 | - |
isoenzyme PAP-II | Homo sapiens |
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