Literature summary for 3.1.3.18 extracted from

Segerer, G.; Hadamek, K.; Zundler, M.; Fekete, A.; Seifried, A.; Mueller, M.J.; Koentgen, F.; Gessler, M.; Jeanclos, E.; Gohla, A.
An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation (2016), Sci. Rep., 6, 35160 .

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Protein Variants

Protein Variants	Comment	Organism
D34N	phosphatase-inactive mutant. Knockin replacement of murine Pgp with its D34N mutant is embryonically lethal	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8CHP8	cf. 3.1.3.48	-

General Information

General Information	Comment	Organism
physiological function	replacement of murine Pgp with its phosphatase-inactive PgpD34N mutant is embryonically lethal due to intrauterine growth arrest and developmental delay in midgestation. PGP inactivation attenuates triosephosphate isomerase activity, increases triglyceride levels at the expense of the cellular phosphatidylcholine content, and inhibits cell proliferation. These effects are prevented under hypoxic conditions or by blocking phosphoglycolate release from damaged DNA	Mus musculus

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Release 2023.1 (January 2023)