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Literature summary for 3.1.3.16 extracted from
- Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases (2015), Biochim. Biophys. Acta, 1854, 1768-1775 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic isotope effects. The active form of the substrate is the dianion | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [a protein]-serine/threonine phosphate + H2O | Homo sapiens | - |
[a protein]-serine/threonine + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P51452 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | human protein VHR is a dual specificity protein phosphatase 3, that also exhibits tyrosine phosphatase activity, EC 3.1.3.48 | Homo sapiens | ? | - |
? | |
| [a protein]-serine/threonine phosphate + H2O | - |
Homo sapiens | [a protein]-serine/threonine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dual specificity protein phosphatase 3 | UniProt | Homo sapiens |
| More | cf. EC 3.1.3.48 | Homo sapiens |
| VHR | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme is a member of the PTP superfamily, but VHR is a dual-specific enzyme (a DSP) | Homo sapiens |
| additional information | phosphatases do not alter the transition state for phosphoryl transfer | Homo sapiens |
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Release 2023.1 (January 2023)
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